Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The thalamic changes in progressive supranuclear palsy].

N Amano1, H Nagatomo, S Yokoi

  • 1Division of Neuro-psychiatry, Kanagawa Rehabilitation Center, Japan.

No to Shinkei = Brain and Nerve
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of the superimposed laser shot number for copper using a deep convolutional neural network.

Optics express·2023
Same author

Taphonomy and chronosequence of the 709 ka Kalinga site formation (Luzon Island, Philippines).

Scientific reports·2020
Same author

Development of a high-hydrous gel phantom for human body communication based on electrical anisotropy.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020
Same author

Direct observation of imploded core heating via fast electrons with super-penetration scheme.

Nature communications·2019
Same author

Local outbreak of Streptococcus pneumoniae serotype 12F caused high morbidity and mortality among children and adults.

Epidemiology and infection·2018
Same author

Earliest known hominin activity in the Philippines by 709 thousand years ago.

Nature·2018

Neuropathological changes in the thalamus, including neurofibrillary tangles (NFTs) and neuronal loss, are common in progressive supranuclear palsy (PSP). These thalamic alterations may contribute to dementia, stupor, and akinetic mutism in PSP patients.

Area of Science:

  • Neuropathology
  • Neuroscience
  • Geriatric Medicine

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by progressive dementia.
  • The thalamus's role in PSP neuropathology and its contribution to clinical symptoms remain incompletely understood.

Observation:

  • This study examined neuropathological changes in the thalamus of six autopsy-confirmed PSP cases.
  • Histological analysis included neuronal loss, fibrillary gliosis, and neurofibrillary tangles (NFTs) using various staining techniques.
  • Specific thalamic nuclei and the zona incerta were evaluated for pathological alterations.

Findings:

  • Three distinct neuropathological patterns were identified in the thalamus among the six cases.
  • Common findings included neuronal loss and NFTs, particularly in medial, lateral, and ventral nuclei, as well as the zona incerta.

Related Experiment Videos

  • Argentophilic fibrillary inclusions were present in the neuropil and astrocytes across all cases.

    • Implications:

    • Thalamic neuropathology in PSP, including NFTs and neuronal loss, may be crucial in the development of dementia, stupor, and akinetic mutism.
    • Further research correlating specific thalamic changes with clinical manifestations is warranted to understand PSP's complex presentation.
    • Understanding these thalamic alterations could inform diagnostic and therapeutic strategies for progressive supranuclear palsy.