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[Effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis]
Zheng-xin Liu1, Bao-wen Chen, Gui-bin Yang
1Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China. liuzhengx2003@vip.sina.com
Objective:
To study the effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis.
Methods:
Fifty-six gastritis patients with or without Helicobacter pylori infection (Hp+ 27; Hp- 29) were selected. The expression of proliferation cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR), transforming growth factor beta receptor type I and type II(TGFbetaRI, TGFbetaRII) in gastric mucosa were examined by immunohistochemical method.
Results:
The PCNA and EGFR were significantly higher in Hp positive chronic gastritis patients than in Hp negative ones(P<0.05); The TGFbetaRI(P=0.16) and TGFbetaRII(P=0.97) were lower.
Conclusion:
Hp infection promotes over proliferation of gastric mucosal cells.
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