[Enhanced prognostic information by determining hs CRP on metabolic syndrome]

Long-term observation studies on metabolic syndrome have disclosed that accumulation of clinical features in the syndrome indicated poor prognosis in the subjects. High sensitivity CRP(hs CRP) is generally increased in the obese subjects due to increased TNF alpha and IL-6 in adipose tissue. Hs CRP is also elevated in hypertensive and diabetic subjects. Hs CRP is increased in the subjects with low HDL-cholesterol and high triglyceride. The West of Scotland Coronary Prevention Study indicated that metabolic syndrome with or without hs CRP more than 3 mg/l predicted definite differences in prognosis for future cardiac outcomes.