[Clinical trials to evaluate interventions aimed to prevent or delay the development of diabetes in high risk IGT]

Numerous clinical trials have been completed to evaluate interventions aimed to prevent or delay the development of diabetes in high risk populations and ultimately to reduce the risk of CVD. There have been several trials emphasizing lifestyle modification, including weight reduction and increased physical activity, such as the Da Qing Study, the Finnish Diabetes Prevention Study and the Diabetes Prevention Program. Pharmacologic agents such as metformin, alpha-glucosidase inhibitors, and TZDs have also been shown to reduce the risk of developing type 2 diabetes.