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[Castleman's disease: a case report].

E Cammisuli1, V Catania, A Santuccio

  • 1Cattedra di Chirurgia Oncologica dell'Università di Catania.

Annali Italiani Di Chirurgia
|June 23, 2004
PubMed
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Castleman disease is a rare lymphoproliferative disorder. This case highlights a rare pediatric presentation of the hyaline-vascular type, successfully treated with surgery.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Castleman disease (CD) is a rare lymphoproliferative disorder of unknown etiology.
  • Suspected factors include interleukin-6 (IL-6) dysregulation and human herpesvirus 8 (HHV-8) in immunocompromised individuals.
  • CD presents in localized or multicentric forms, with hyaline-vascular and plasma cell subtypes.

Observation:

  • A 21-year-old female presented with pelvic pain and amenorrhea.
  • Imaging revealed a 4.5 cm retroperitoneal mass adjacent to the uterus and iliac vessels.
  • Previous laparoscopy diagnosed an endometrial cyst; a subsequent laparoscopy partially excised the mass.

Findings:

  • Histological examination confirmed the hyaline-vascular type of Castleman disease.
  • The patient underwent successful surgical laparotomy for complete mass excision.

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  • Post-surgery, the patient remained asymptomatic for three years.

    • Implications:

    • This case underscores the importance of considering Castleman disease in the differential diagnosis of retroperitoneal masses.
    • Surgical excision offers a potentially curative option for localized hyaline-vascular CD.
    • Further research is needed to elucidate the etiology and optimize treatment strategies for CD.