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Related Experiment Videos

[Systemic candidiasis and infliximab therapy].

A Belda1, J Hinojosa, B Serra

  • 1Unidad de Aparato Digestivo, Servicio de Medicina Interna, Hospital de Sagunto, Sagunto, Valencia, España.

Gastroenterologia Y Hepatologia
|June 23, 2004
PubMed
Summary

Infliximab is used for Crohn's disease. A case study suggests infliximab, with steroids and azathioprine, may increase the risk of systemic fungal infections in Crohn's patients.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Crohn's disease (CD) is a chronic inflammatory bowel disease.
  • Infliximab is an effective biologic therapy for refractory CD.
  • Concomitant use of immunosuppressants is common in CD management.

Observation:

  • A patient with refractory Crohn's disease was treated with infliximab, corticosteroids, and azathioprine.
  • The patient developed systemic candidiasis, a serious fungal infection.
  • While infliximab's overall infection risk is not elevated, anecdotal reports of fungal infections exist.

Findings:

  • This case highlights a potential association between infliximab therapy and systemic fungal infections.
  • The combination of infliximab with corticosteroids and azathioprine may enhance this risk.

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  • Further investigation is warranted to understand this potential complication.

    • Implications:

    • Clinicians should be vigilant for systemic fungal infections in Crohn's disease patients on infliximab, especially with combination immunosuppressive therapy.
    • This case contributes to the understanding of rare but serious adverse events associated with biologic therapies.
    • Monitoring and early detection of fungal infections are crucial for patient safety in advanced Crohn's disease management.