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36:30
Small Bowel Transplantation In Mice
Published on: August 20, 2007
[Therapeutic alternatives in intestinal failure]
J M Moreno Villares1, M J Galiano Segovia, P Urruzuno Tellería
1Unidad de Nutrición Clínica, Hospital Universitario 12 de Octubre, Ctra. de Andalucía, km. 5,400, 28041 Madrid, Spain. jmoreno.hdoc@salud.madrid.org
Anales De Pediatria (Barcelona, Spain : 2003)
|June 23, 2004
Summary
Home parenteral nutrition (HPN) is an effective interim treatment for intestinal failure, aiding intestinal adaptation. Intestinal transplantation (IT) is reserved for severe HPN complications, with both treatments considered complementary.
Area of Science:
- Gastroenterology
- Surgical Sciences
Context:
- Long-term parenteral nutrition (PN) and intestinal transplantation (IT) are key treatments for intestinal failure.
- Choosing between PN and IT requires balancing their respective advantages and disadvantages.
Purpose:
- To analyze the outcomes of home parenteral nutrition (HPN) for patients with intestinal failure.
- To assess patient suitability for IT in the context of HPN treatment.
Summary:
- Intestinal failure was defined as requiring PN for over 5 months.
- Of 14 HPN patients, 9 had intestinal failure (motility disorder, short bowel syndrome, protracted diarrhea).
- Five patients weaned off HPN due to adaptation; one died; three remain on HPN. All eligible patients were IT candidates.
Impact:
- Intestinal rehabilitation is optimal for intestinal failure.
- HPN serves as a crucial interim therapy during the wait for intestinal adaptation.
- Intestinal transplantation (IT) should be reserved for severe HPN complications, but is a viable option for indefinite HPN cases.
- HPN and IT are complementary treatments for intestinal failure.
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