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Plague

C Glenn Cobbs1, David H Chansolme

  • 1Division of Infectious Disases, Department of Medicine, School of Medicine, University of Alabama at Birmingham, THT 229, 1530 3rd Avenue South, Birmingham, AL 35294, USA. gcobbs@uab.edu

Dermatologic Clinics
|June 23, 2004
PubMed

Insights

Plague, a disease caused by Yersinia pestis, remains a global threat with diverse clinical forms. Early diagnosis and immediate treatment are crucial to reduce severe outcomes and mortality.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Plague is an ancient infectious disease with a worldwide distribution.
  • It manifests in several clinical forms, including bubonic, pneumonic, and septicemic plague.
  • Yersinia pestis poses a significant bioterrorism risk.

Purpose of the Study:

  • To provide an overview of plague, its clinical presentations, and its potential as a bioterrorism agent.
  • To emphasize the importance of prompt diagnosis and treatment.

Main Methods:

  • Review of historical and contemporary medical literature on plague.
  • Discussion of clinical manifestations and diagnostic considerations.
  • Assessment of Yersinia pestis as a potential bioterrorism threat.

Main Results:

  • Plague presents globally in various forms, such as bubonic, pneumonic, and septicemic.
  • Early presumptive diagnosis is possible with standard techniques.
  • Laboratory handling of specimens requires specialized precautions.

Conclusions:

  • Immediate treatment initiation upon suspicion of plague is critical.
  • Delayed therapy significantly increases morbidity and mortality.
  • Understanding plague's diverse presentations and bioterrorism potential is vital for public health preparedness.

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