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Related Experiment Videos

Controlled cisplatin delivery system using poly(D,L-lactic acid).

O Ike1, Y Shimizu, R Wada

  • 1Research Center for Biomedical Engineering, Kyoto University, Japan.

Biomaterials
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Poly(D,L-lactic acid) microspheres and beads loaded with cisplatin (CDDP) were developed. The beads demonstrated sustained cisplatin release in vitro and in vivo, with minimal tissue damage.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Oncology

Background:

  • Cisplatin (CDDP) is a widely used chemotherapy drug.
  • Developing effective drug delivery systems is crucial for improving cancer treatment outcomes.
  • Poly(D,L-lactic acid) (PDLLA) is a biodegradable polymer suitable for drug encapsulation.

Purpose of the Study:

  • To prepare and characterize cisplatin-loaded poly(D,L-lactic acid) microspheres (CDDP-MS) and beads (CDDP-B).
  • To evaluate the in vitro and in vivo release kinetics of CDDP from CDDP-B.
  • To assess the histological effects of CDDP-B in vivo.

Main Methods:

  • Preparation of CDDP-MS and CDDP-B with varying PDLLA molecular weights and CDDP loading.
  • In vitro release studies in Tris buffer.

Related Experiment Videos

  • In vivo release studies.
  • Histological examination of tissues surrounding implanted CDDP-B.

    • Main Results:

    • CDDP-MS showed rapid CDDP release, with 95% disappearance within 3 days.
    • CDDP-B exhibited sustained CDDP release over 30-57 days (in vitro) and 21-42 days (in vivo).
    • A two-phase release pattern was observed for a specific CDDP-B formulation, with complete release within 41 days (in vitro) and 21 days (in vivo).
    • Histological analysis revealed no severe tissue necrosis around CDDP-B.

    Conclusions:

    • Poly(D,L-lactic acid) beads provide a promising sustained release system for cisplatin.
    • The developed CDDP-B formulations show potential for localized chemotherapy delivery with a favorable safety profile.
    • Further studies are warranted to optimize PDLLA properties for enhanced therapeutic efficacy.