Related Experiment Video
Updated: Jun 26, 2026
Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique
Published on: March 14, 2016
Immunotherapy: 1999-2004
1Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. pnorman@jhmi.edu
Allergen immunotherapy effectively manages allergic rhinitis and asthma by suppressing allergic immune responses. Research is ongoing to improve allergen vaccines and administration routes for better patient outcomes.
Area of Science:
- Immunology
- Allergy and Asthma Research
Background:
- Allergen immunotherapy is a globally utilized treatment for allergic rhinitis and asthma.
- Ongoing research refines understanding of immunotherapy's indications, effective allergens, and optimal administration parameters.
Purpose of the Study:
- To review current knowledge and advancements in allergen immunotherapy.
- To discuss immunologic changes, safety, and efficacy of different administration routes.
Main Methods:
- Review of controlled studies on immunotherapy efficacy and immunologic changes.
- Analysis of data regarding sublingual immunotherapy (SLIT) safety and dosage.
Main Results:
- T(H)2 lymphocyte responses are suppressed, and T(H)1 responses are stimulated post-immunotherapy.
- Eosinophil and basophil inflammatory responses are downregulated.
- Sublingual immunotherapy is safe and effective with adequate dosing.
Conclusions:
- Allergen immunotherapy remains a key treatment for allergic diseases.
- Further research into allergen vaccine modifications is promising but not yet clinically available.
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