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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Immunotherapy of Allergic Disorders: Traditional and Novel Approaches.

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Related Experiment Video

Updated: Jun 26, 2026

Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique
05:18

Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique

Published on: March 14, 2016

Immunotherapy: 1999-2004.

Philip S Norman1

  • 1Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. pnorman@jhmi.edu

The Journal of Allergy and Clinical Immunology
|June 23, 2004
PubMed
Summary
This summary is machine-generated.

Allergen immunotherapy effectively manages allergic rhinitis and asthma by suppressing allergic immune responses. Research is ongoing to improve allergen vaccines and administration routes for better patient outcomes.

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Area of Science:

  • Immunology
  • Allergy and Asthma Research

Background:

  • Allergen immunotherapy is a globally utilized treatment for allergic rhinitis and asthma.
  • Ongoing research refines understanding of immunotherapy's indications, effective allergens, and optimal administration parameters.

Purpose of the Study:

  • To review current knowledge and advancements in allergen immunotherapy.
  • To discuss immunologic changes, safety, and efficacy of different administration routes.

Main Methods:

  • Review of controlled studies on immunotherapy efficacy and immunologic changes.
  • Analysis of data regarding sublingual immunotherapy (SLIT) safety and dosage.

Main Results:

  • T(H)2 lymphocyte responses are suppressed, and T(H)1 responses are stimulated post-immunotherapy.
  • Eosinophil and basophil inflammatory responses are downregulated.
  • Sublingual immunotherapy is safe and effective with adequate dosing.

Conclusions:

  • Allergen immunotherapy remains a key treatment for allergic diseases.
  • Further research into allergen vaccine modifications is promising but not yet clinically available.