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[Study on the injury effect of ammonium perchlorate to lung]
Haibing Yang1, Kailiang Peng, Qilong Chu
1Public Health School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Objective:
To study the injury effect of ammonium perchlorate (AP) to lung and to explore whether AP can cause pulmonary fibrosis.
Methods:
To detect the levels of cell counts, TNF-alpha, MDA, HYP and the synthesis of collagen in BALF or rat lung after a certain time when rats were injected AP by intratracheal instillation.
Results:
AP could bring about acute lung damage and inflammatory reaction. The levels of TNF-alpha of different groups in different time were obviously higher than the normal control group(P < 0.05). AP could affect the levels of MDA, HYP and the synthesis of collagen. But it had no obviously pathological change of pulmonary fibrosis.
Conclusion:
There were acute injury effect about AP to lung, but this experiment could not make sure whether AP could cause pulmonary fibrosis.
