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Updated: Aug 10, 2026
Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
[Study of glycolaldehyde on DNA damage in mouse spleen lymphocytes]
Yajing Liang1, Cai Li, Fangyu Hou
1Institute of Frontier Medical Science, Jilin University, Changchun 130021, China.
Objective:
Study the effect of glycolaldehyde on DNA of mouse spleen lymphocytes.
Methods:
The DNA damage induced by different concentrations of glycolaldehyde was detected using single cell gel electrophoresis assay (SCGE).
Results:
Glycolaldehyde at 0.01 mmol/L could induce lymphocyte DNA strand breakage and DNA damage rate was 8% and, the average migration distance of DNA was (14.32 +/- 2.84) micron. DNA damage rate and the average migration distance of DNA were increased in a concentration-dependent manner.
Conclusion:
glycolaldehyde could induce DNA damage in different concentration in this experiment.
