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Dynamic tests to study liver function.

P Burra1, A Masier

  • 1Gastroenterology Section, Department of Surgical and Gastroenterological Sciences, University of Padova, Italy.

European Review for Medical and Pharmacological Sciences
|June 24, 2004
PubMed
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Quantitative liver function tests assess hepatic clearance and synthesis. While not ideal for initial screening, these tests excel at monitoring liver dysfunction severity, offering superior insights compared to standard biochemical tests.

Area of Science:

  • Hepatology
  • Clinical Chemistry
  • Pharmacology

Background:

  • Liver function is assessed via synthesis products or clearance.
  • Exogenous dyes like sulphobromophthalein (BSF) and indocyanine green (ICG) can evaluate liver function.
  • Metabolism rates of non-toxic substances in vivo offer another measure of hepatic function.

Purpose of the Study:

  • To review quantitative liver function tests.
  • To highlight their utility in monitoring liver dysfunction.
  • To contrast their application with conventional screening methods.

Main Methods:

  • Review of established quantitative liver function tests.
  • Discussion of substances used: antipyrine, caffeine, galactose, MEGX.
  • Comparison of test complexity, cost, and diagnostic utility.

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Main Results:

  • Antipyrine clearance correlates well with liver damage severity.
  • Caffeine clearance is useful for severe lesions but not moderate ones.
  • Galactose clearance aids in differentiating hepatocellular disease from biliary obstruction early in jaundice.
  • MEGX test provides real-time quantitative assessment of liver function, particularly pre- and post-transplant.

Conclusions:

  • Quantitative liver function tests are not suitable for initial liver disease screening.
  • Despite higher complexity and cost, these tests are superior for monitoring the degree of liver dysfunction.