Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetic nephropathy and beta-cell replacement therapy.

J W de Fijter1

  • 1Department of Nephrology (C3-P22), Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands. jwdefijter@lumc.nl

The Netherlands Journal of Medicine
|June 24, 2004
PubMed
Summary

Whole pancreas transplantation offers a reliable solution for type 1 diabetes, restoring insulin secretion and preventing complications. However, risks and the need for long-term immunosuppression must be considered for pancreas and kidney transplants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diabetes screening in dialysis populations with a glucose challenge test and continuous glucose monitoring-DIGEST study.

Diabetes, obesity & metabolism·2025
Same author

Attenuation of Torque teno viral load over time in kidney transplantation recipients treated with calcineurin inhibitors is mitigated after conversion to belatacept.

Journal of medical virology·2024
Same author

Conversion from calcineurin inhibitors to belatacept-based immunosuppressive therapy skews terminal proliferation of non-classical monocytes and lowers lymphocyte counts.

Transplant immunology·2024
Same author

Presence of CD163<sup>+</sup> macrophages in DCD kidneys with high DGF reduces the risk for acute cellular rejection in 6 months after kidney transplantation.

Transplant immunology·2022
Same author

Rational selection of a biomarker panel targeting unmet clinical needs in kidney injury.

Clinical proteomics·2021
Same author

Source and Relevance of the BK Polyomavirus Genotype for Infection After Kidney Transplantation.

Open forum infectious diseases·2019

Area of Science:

  • Endocrinology
  • Transplantation Immunology
  • Nephrology

Background:

  • Type 1 diabetes mellitus (T1DM) necessitates management of endogenous insulin secretion and diabetic complications.
  • Whole pancreas transplantation is an established method for T1DM, aiming for long-term normoglycemia.
  • Simultaneous pancreas and kidney transplantation (SPKT) outcomes on diabetic complications are variable, influenced by diabetes duration.

Purpose of the Study:

  • To evaluate the efficacy and risks associated with whole pancreas transplantation in managing type 1 diabetes mellitus.
  • To assess the impact of simultaneous pancreas and kidney transplantation on diabetic complications.
  • To discuss the balance between potential benefits and risks, including immunosuppression, for pancreas transplant recipients.

Main Methods:

Related Experiment Videos

  • Review of existing literature on whole pancreas transplantation and SPKT outcomes.
  • Analysis of the impact of long-standing diabetes on transplant outcomes.
  • Consideration of peroperative morbidity and long-term immunosuppressive requirements.

Main Results:

  • Whole pancreas transplantation effectively restores endogenous insulin secretion and can prevent or reverse diabetic complications.
  • SPKT's effect on diabetic complications is variable, particularly in patients with long diabetes duration (over two decades).
  • Long-term normoglycemia is achievable with whole pancreas transplantation, but requires careful risk-benefit assessment.

Conclusions:

  • Whole pancreas transplantation remains the sole reliable option for achieving long-term normoglycemia in type 1 diabetes.
  • The success of islet transplantation hinges on islet longevity and improved immunosuppressive strategies that protect beta-cells from autoimmune destruction.
  • Balancing the benefits of transplantation against surgical risks and lifelong immunosuppression is crucial for patient management.