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Elevated iron indices in patients with diabetes
M C Thomas1, R J MacIsaac, C Tsalamandris
1Department of Medicine, University of Melbourne, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia. mthomas@baker.edu.au
Summary
Elevated iron indices are more common in patients with diabetes, particularly Type 1 and Type 2. Excess iron may influence diabetes development and glycemic control, but isn't linked to complications.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Iron Metabolism
Background:
- Excess iron is linked to diabetes pathogenesis and complications.
- Understanding iron indices in diabetes is crucial for patient management.
Purpose of the Study:
- To assess plasma iron indices in diabetic patients.
- To correlate transferrin saturation with clinical and biochemical parameters.
Main Methods:
- Cross-sectional survey of 820 diabetic patients.
- Recorded plasma iron indices and clinical/biochemical profiles over 2 years.
- Used regression analysis to identify predictors of transferrin saturation.
Main Results:
- Prevalence of elevated transferrin saturation (>35%) was 3-4 times higher in diabetics.
- Associated with male gender, low C-reactive protein, and high fasting glucose.
- Type 1 diabetes patients had higher odds of elevated transferrin saturation (OR 3.9).
- No correlation found between elevated iron indices and diabetic complications.
Conclusions:
- Elevated iron indices are more prevalent in diabetic individuals.
- Excess iron may play a role in diabetes development and glycemic control.
- Iron indices are strongly associated with anemia in diabetic patients.