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Embryotoxicity of 25 psychotropic drugs: a study using CHEST
M Peterka1, R Jelínek, A Pavlík
1Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Praha.
Reproductive Toxicology (Elmsford, N.Y.)
|January 1, 1992
Abstract:
Twenty five psychotropic drugs were ranked according to the embryotoxicity dose ranges estimated by the Chick Embryotoxicity Screening Test (CHEST). The chick results were compared with some data for common laboratory mammals. In 17 psychotropic drugs a deleterious dose-dependent effect upon the embryonic cardiovascular system was disclosed, terminating in immediate cardiac arrest.