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Published on: October 11, 2022
Synthesis and antiangiogenic activity of thioacetal artemisinin derivatives
Sangtae Oh1, In Howa Jeong, Chan Mug Ahn
1Department of Chemistry, Yonsei University, Wonju 220-710, South Korea.
Abstract:
Various thioacetal artemisinin derivatives can inhibit the angiogenesis and might be angiogenesis inhibitors. In particular, 10 alpha-phenylthiodihydroartemisinins (5), 10 beta-benzenesulfonyl-9-epi-dihydroartemisinin (11) and 10 alpha-mercaptodihydroartemisinin (13) exhibit strong growth inhibition activity against HUVEC proliferation. Compound 11 have a good inhibitiory activity upon HUVEC tube formation, and 5 and 11 show a strong inhibitory effect on angiogenesis using CAM assay at 5 microg/egg by 90%.
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