Related Experiment Video
Updated: Aug 23, 2026

Immunolabelling Myofiber Degeneration in Muscle Biopsies
Published on: December 5, 2019
Myofibrillar myopathy with desmin accumulation in a young Australian Shepherd dog
G Diane Shelton1, Veronique Sammut, Saschiko Homma
1Department of Pathology, University of California San Diego, La Jolla, CA 92093-0709, USA. gshelton@ucsd.edu
Abstract:
A 1-year-old male neutered Australian Shepherd dog was referred to a veterinary specialist for evaluation of chronic lameness, contractures, and exercise intolerance. Serum creatine kinase was elevated, and electromyography showed complex repetitive discharges. Cardiomyopathy was clinically identified. Muscle biopsies evaluated by light and electron microscopy, and immunohistochemistry revealed the presence of a myofibrillar myopathy with accumulation of desmin and other proteins. These observations represent the first report of myofibrillar myopathy in the dog.
Related Concept Videos
Satellite Stem Cells and Muscular Dystrophy
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Microscopic Anatomy of Skeletal Muscles
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
Cardiomyopathy III: Hypertrophic Cardiomyopathy
