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Related Experiment Videos

Neuropsychological functioning in end-stage renal disease.

H N Bawden1, P Acott, J Carter

  • 1Department of Pediatrics, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada. harry.bawden@iwk.nshealth.ca

Archives of Disease in Childhood
|June 24, 2004
PubMed
Summary

Children with end-stage renal disease (ESRD) show mild deficits in intelligence and motor skills compared to siblings. However, their overall neuropsychological functioning is better than previously reported.

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Area of Science:

  • Pediatric Nephrology
  • Neuropsychology
  • Child Development

Background:

  • End-stage renal disease (ESRD) significantly impacts children's health.
  • Neuropsychological and behavioral outcomes in pediatric ESRD require further investigation.

Purpose of the Study:

  • To compare neuropsychological functioning and behavior in children with non-syndromic ESRD and their siblings.
  • To assess intelligence, academic achievement, memory, motor abilities, behavior, and self-esteem.

Main Methods:

  • Evaluated 22 pediatric patients with ESRD (on transplant waiting list, dialysis, or pending dialysis) and their sibling controls.
  • Administered neuropsychological assessments including IQ, academic achievement, memory, and motor tests.
  • Collected maternal ratings of behavior and self-reported self-esteem.

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Main Results:

  • ESRD patients had significantly lower Verbal, Performance, and Full Scale IQs (mean differences of 8.6, 11.7, and 10.9 points, respectively).
  • ESRD patients demonstrated greater difficulties in fine motor coordination and copying geometric designs.
  • No significant differences were found in academic achievement, memory, behavior, or self-esteem between groups.

Conclusions:

  • Children with ESRD exhibit mild intellectual and some motor deficits compared to sibling controls.
  • The neuropsychological outcome for children with ESRD appears more favorable than suggested by earlier studies.