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Published on: July 3, 2013
Neuropsychological functioning in end-stage renal disease
H N Bawden1, P Acott, J Carter
1Department of Pediatrics, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada. harry.bawden@iwk.nshealth.ca
Archives of Disease in Childhood
|June 24, 2004
Summary
Children with end-stage renal disease (ESRD) show mild deficits in intelligence and motor skills compared to siblings. However, their overall neuropsychological functioning is better than previously reported.
Area of Science:
- Pediatric Nephrology
- Neuropsychology
- Child Development
Background:
- End-stage renal disease (ESRD) significantly impacts children's health.
- Neuropsychological and behavioral outcomes in pediatric ESRD require further investigation.
Purpose of the Study:
- To compare neuropsychological functioning and behavior in children with non-syndromic ESRD and their siblings.
- To assess intelligence, academic achievement, memory, motor abilities, behavior, and self-esteem.
Main Methods:
- Evaluated 22 pediatric patients with ESRD (on transplant waiting list, dialysis, or pending dialysis) and their sibling controls.
- Administered neuropsychological assessments including IQ, academic achievement, memory, and motor tests.
- Collected maternal ratings of behavior and self-reported self-esteem.
Main Results:
- ESRD patients had significantly lower Verbal, Performance, and Full Scale IQs (mean differences of 8.6, 11.7, and 10.9 points, respectively).
- ESRD patients demonstrated greater difficulties in fine motor coordination and copying geometric designs.
- No significant differences were found in academic achievement, memory, behavior, or self-esteem between groups.
Conclusions:
- Children with ESRD exhibit mild intellectual and some motor deficits compared to sibling controls.
- The neuropsychological outcome for children with ESRD appears more favorable than suggested by earlier studies.
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