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Related Experiment Videos

Delayed poststroke dementia: a 4-year follow-up study.

M Altieri1, V Di Piero, M Pasquini

  • 1Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy. marta.altieri@uniroma1.it

Neurology
|June 24, 2004
PubMed
Summary

Delayed poststroke dementia (dPSD) developed in 21.5% of patients over 4 years. Characteristics like cortical atrophy, age, and multiple lesions predicted dPSD, which shifted from Alzheimer

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Area of Science:

  • Neurology
  • Neuroscience
  • Geriatrics

Background:

  • Stroke is a leading cause of disability, increasing dementia risk.
  • Poststroke dementia (PSD) is a significant long-term complication.
  • Delayed PSD (dPSD) characteristics and progression require further investigation.

Purpose of the Study:

  • To assess the incidence of delayed poststroke dementia (dPSD).
  • To identify predictors of dPSD development.
  • To characterize the evolution of dPSD over a 4-year follow-up period.

Main Methods:

  • Longitudinal follow-up of 191 non-demented stroke patients for 4 years.
  • Dementia diagnosis using ICD-10 criteria; etiology using established neurological criteria.
  • Annual neuroimaging, neuropsychological testing, and clinical assessments.

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Main Results:

  • Dementia developed in 41 (21.5%) patients by study end.
  • Cox regression identified cortical atrophy (HR=3.4), age (HR=3.3), and multiple ischemic lesions (HR=2.5) as significant dPSD predictors.
  • Kaplan-Meier analysis revealed significant differences in dPSD subtype incidence (p=0.002).

Conclusions:

  • The incidence of dementia increased gradually over 4 years post-stroke.
  • The dementia profile shifted from an Alzheimer's disease-type presentation early on to a vascular dementia-type later.
  • Identifying dPSD predictors aids in risk stratification and potential intervention strategies.