Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Closure of abdominal wall defects using acellular dermal matrix.

Gary An1, Robert J Walter, Kimberly Nagy

  • 1Department of Trauma, Stroger Cook County Hospital, Chicago, Illinois, USA.

The Journal of Trauma
|June 24, 2004
PubMed
Summary

Acellular dermal matrix (ADM) is superior to polytetrafluoroethylene (PTFE) for abdominal wall reconstruction. ADM promotes better wound healing and incorporation, even with peritonitis, unlike PTFE which can cause complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical, Radiographic, and Physiological Correlates of Post-COVID-19 Dyspnea in Military Health System Beneficiaries: Results From the Chronic Impairment With Pulmonary Symptoms (ChIPS) Sub-study.

Open forum infectious diseases·2025
Same author

Generating synthetic multidimensional molecular time series data for machine learning: considerations.

Frontiers in systems biology·2025
Same author

Cardiopulmonary Exercise Testing in the Study of Active Duty Military for Pulmonary Disease Related to Environmental Deployment Exposures (STAMPEDE) III.

Respiratory care·2025
Same author

Delivering a Regional Procedural Bootcamp for Incoming Pulmonary and Critical Care Medicine Fellows.

Chest·2025
Same author

Immune digital twins for complex human pathologies: applications, limitations, and challenges.

NPJ systems biology and applications·2024
Same author

Epidemiology and Outcomes Associated with New Persistent Opioid Use after Transabdominal Surgery.

Journal of the American College of Surgeons·2024

Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Wound Healing Research

Background:

  • Large abdominal wall defects often require prosthetic materials for reconstruction.
  • Polytetrafluoroethylene (PTFE) has been a common choice for emergency abdominal wall repair.
  • Tissue loss or visceral swelling can complicate wound closure.

Purpose of the Study:

  • To compare the efficacy of allogenic acellular dermal matrix (ADM) and PTFE in abdominal wall reconstruction.
  • To evaluate wound healing in sterile and contaminated conditions.

Main Methods:

  • A study was conducted on rats with full-thickness abdominal wounds.
  • The efficacy of ADM and PTFE was assessed over 21 days.
  • Peritonitis was experimentally induced in some animals to simulate contaminated conditions.

Related Experiment Videos

Main Results:

  • ADM integrated into the wound bed, vascularized, and epithelialized without grafting.
  • ADM effectively closed wounds, reducing area significantly in both sterile and contaminated settings.
  • PTFE provided temporary closure, led to granulation tissue, bleeding upon removal, and instances of evisceration and fistula formation.

Conclusions:

  • Allogenic acellular dermal matrix (ADM) offers significant advantages over PTFE for abdominal wall defect closure.
  • ADM demonstrates superior performance in promoting healing and reducing complications in both sterile and contaminated environments.
  • ADM is a promising alternative for complex abdominal wall reconstruction.