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Related Experiment Videos

Herbs and the kidney.

Corinne Isnard Bagnis1, Gilbert Deray, Alain Baumelou

  • 1Nephrology Department, Pitié Salpêtrière Hospital, Paris, France. corinne.bagnis@psl.ap-hop-paris.fr

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|June 24, 2004
PubMed
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Herbal remedies can cause serious kidney damage due to undisclosed toxins or interactions, affecting renal patients. Healthcare providers must inquire about herbal product use to prevent adverse renal events.

Area of Science:

  • Nephrology
  • Pharmacology
  • Toxicology

Background:

  • Increased use of herbal therapy globally.
  • Lack of regulation for herbal products as medicines in many countries.
  • Potential for herbal products to cause renal injury and toxic insults.

Purpose of the Study:

  • To highlight the risks associated with herbal therapy in renal patients.
  • To inform healthcare providers about potential adverse renal syndromes linked to medicinal plants.
  • To emphasize the importance of patient screening for herbal product consumption.

Main Methods:

  • Review of reported cases and syndromes associated with herbal product use.
  • Analysis of potential mechanisms of herbal-induced nephrotoxicity.
  • Synthesis of clinical evidence on renal complications from medicinal plants.

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Main Results:

  • Herbal poisoning can result from undisclosed drugs, heavy metals, drug interactions, or misidentified species.
  • Reported renal syndromes include acute interstitial nephritis, tubular necrosis, Fanconi's syndrome, and chronic interstitial nephritis.
  • Other renal effects include electrolyte imbalances, hypertension, nephrolithiasis, and urinary tract cancers.

Conclusions:

  • Herbal therapies pose significant risks to renal patients, leading to diverse nephrotoxic effects.
  • Healthcare providers need to be aware of and question patients regarding herbal product use.
  • Vigilance and patient education are crucial to mitigate underreported adverse events from herbal medicine.