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Craniofacial variability and modularity in macaques and mice.

Benedikt Hallgrímsson¹, Katherine Willmore, Curtis Dorval

¹Department of Cell Biology & Anatomy and the Joint Injury and Arthritis Research Group, University of Calgary, Calgary, Alberta T2N 4N1, Canada. bhalligri@ucalgary.edu

Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution

|June 24, 2004

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Comparing cranial variability in mice and macaques reveals shared patterns, aiding evolutionary developmental biology research. This study bridges mouse models and primate evolution for better insights.

Area of Science:

Evolutionary developmental biology
Primate craniofacial evolution
Comparative morphology

Background:

Mouse models are crucial for understanding primate evolutionary developmental biology.
Comparing phenotypic variation between mice and primates is essential for accurate inferences.
Specific mouse strains (C57BL/6J, A/WySnJ) and rhesus macaques offer valuable datasets.

Purpose of the Study:

To compare cranial variability patterns between laboratory mice and rhesus macaques.
To assess the utility of mouse models for studying primate craniofacial evolution.
To inform research strategies integrating mouse genomics into primate evolutionary developmental biology.

Main Methods:

Utilized morphometric methods to analyze homologous cranial datasets.

Related Experiment Videos

Compared patterns of phenotypic variation and covariation across mouse strains and macaques.

Analyzed genetic and phenotypic variances and developmental stability.

Main Results:

Found significant similarities in covariation patterns between C57BL/6J mice and macaques.
Observed concordance in among-trait variation of genetic and phenotypic variances.
Noted discordance in among-trait variation of developmental stability; modularity patterns were inconsistent.

Conclusions:

Mouse models share significant cranial covariation patterns with macaques, supporting their use in primate evolutionary developmental biology.
Further research is needed to reconcile differences in developmental stability and modularity.
A research strategy integrating mouse genomics and developmental biology is proposed for primate studies.