Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nasal corticosteroids for children with snoring.

Emmanouel I Alexopoulos1, Athanasios G Kaditis, Efthimia Kalampouka

  • 1Department of Pediatrics, University of Thessaly School of Medicine, Larissa, Greece.

Pediatric Pulmonology
|June 24, 2004
PubMed
Summary

Four weeks of nasal budesonide effectively treated mild sleep-disordered breathing in children, improving both polysomnography results and symptoms. The positive effects persisted for months after treatment concluded.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary Alveolar Proteinosis in Greece-Türkiye-Cyprus: Answers in a Real-Life Comparison.

Respirology (Carlton, Vic.)·2026
Same author

Cigarette Smoke Extract Exposure Affects Innate Immune Response, Metabolic Rate, and Locomotor Activity of Drosophila melanogaster.

Lung·2026
Same author

Artificial intelligence for nocturnal oximetry-based diagnosis of OSAS in children younger than 2 years: time to end the polysomnography monocracy?

Sleep·2026
Same author

Nocturnal hypoxemia in infants with or without upper airway obstruction and its association with nocturnal pulse rate.

Sleep medicine·2025
Same author

Nocturnal oximetry profile in hospitalized children with asthma exacerbation upon hospital discharge.

Sleep medicine·2025
Same author

Nocturnal oximetry in infants: Reference values and diagnostic accuracy for upper airway obstruction.

Respiratory medicine·2025

Area of Science:

  • Pediatric Sleep Medicine
  • Respiratory Medicine
  • Pharmacology

Background:

  • Previous research indicated nasal corticosteroids improve objective sleep measures but not subjective symptoms in children with sleep-disordered breathing.
  • Mild sleep-disordered breathing, characterized by habitual snoring and a mild apnea-hypopnea index, often presents with unclear treatment benefits.
  • The efficacy of nasal corticosteroids in concurrently improving polysomnography findings and symptoms in this specific pediatric subgroup required further investigation.

Purpose of the Study:

  • To determine if a 4-week course of nasal budesonide improves both polysomnography indices and symptom scores in children with mild sleep-disordered breathing.
  • To assess the durability of treatment effects on sleep parameters and symptoms following the cessation of nasal corticosteroid administration.

Related Experiment Videos

Main Methods:

  • A study involving 27 children aged 2–14 years with habitual snoring and an apnea-hypopnea index of 1–10 episodes/hr.
  • Participants received budesonide 50 mcg per nostril twice daily for 4 weeks.
  • Evaluations included polysomnography and symptom scoring at baseline, 2 weeks post-treatment, and 9 months post-treatment.

Main Results:

  • Significant improvements were observed in polysomnography findings, with a decrease in the mean apnea-hypopnea index from 5.2 to 3.2 episodes/hr (P < 0.0001).
  • Median oxygen desaturation of hemoglobin index also decreased significantly from 3.1 to 1.9 (P < 0.0001).
  • Symptom scores showed a significant reduction from baseline, decreasing at 2 weeks post-treatment and remaining improved at 9 months (P < 0.05).

Conclusions:

  • Four weeks of nasal budesonide treatment is effective in improving both objective polysomnography measures and subjective symptoms in children with mild sleep-disordered breathing.
  • The beneficial clinical effects of nasal budesonide for mild sleep-disordered breathing in children are sustained for at least several months after treatment completion.
  • Nasal corticosteroids represent a viable therapeutic option for managing mild sleep-disordered breathing in pediatric populations.