Related Experiment Video
Updated: Aug 23, 2026
Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
Published on: February 6, 2012
[Chromosome aberration analysis of peripheral lymphocytes in workers exposed to benzene]
Zhiying Ji1, Guilan Li, Linglin Li
1Institute for Occupational Health and Poison Control, China CDC, Beijing 100050, China.
Objective:
To study the effects of benzene exposure on chromosome aberration of peripheral lymphocytes in workers.
Methods:
Measure the benzene concentration with 3M passive dosimetry badges and analyze chromosome aberrations of peripheral lymphocytes using non-banding method.
Results:
The numerically aberrated cell rate of the workers exposed by benzene [13.00% (2.50%-21.00%)] was significantly higher than that of the controls [10.50% (3.50%-18.00%)] (P < 0.05), and the aberrated cell rate (excluded gaps) [14.50% (5.00%-23.50%)] was significantly higher than that of the controls [11.75(3.50-18.00)] (P < 0.05), too; the P values of the dose-effect relationships between hyperploidy cell rate, numerically aberrated cell rate and aberrated cell rate (excluded gaps) and 8 h-TWA were 0.0008, 0.3741 and 0.2816, respectively, and the P values of the dose-effect relationships between those and the cumulative exposure were 0.0009, 0.0376 and 0.0486, respectively; the premature centromere division cell rate of the benzene-exposed workers [1.75% (0-19.50%)] was not significantly higher than that of the controls [1.00% (0-15.00%)] (P > 0.05).
Conclusion:
Benzene exposure resulted in an increase of chromosome aberrations of the peripheral lymphocytes, which was in a dose-effect relationship manner; whether benzene exposure could induce premature centromere division deserves further studies.
