Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Decrease of affinity between arterial proteoglycans and LDL isolated from smokers and non-smokers with vitamin E and

Luz Barón¹, Eduardo Romero-Vecchione, Flor López

¹Cátedra de Bioquímica, Laboratorio de Lipoproteínas, Escuela de Medicina José María Vargas, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela. publique@cantv.net

Investigacion Clinica

|June 24, 2004

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Epicardial adipose tissue and its association to plasma adrenomedullin levels in patients with metabolic syndrome].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion·2011

Same author

[Effect of sulodexide on aortic vasodilation capacity and associated morphological changes in rats with streptozotocin-induced diabetes].

Investigacion clinica·2011

Same author

High plasma phospholipase A2 activity, inflammation markers, and LDL alterations in obesity with or without type 2 diabetes.

Obesity (Silver Spring, Md.)·2010

Same author

[Cardiovascular responses to hypertonic NaCI injection into the anteroventral third ventricle region in rats with fructose-induced hypertension and insulin resistance].

Revista espanola de cardiologia·2007

Same author

Cardiovascular excitatory effect on rats of a fraction isolated from the eyestalk of shrimp: Peneaus vanameii.

Investigacion clinica·2006

Same author

[Synergistic antioxidative effect of vitamins E and C on low density lipoproteins from smokers and non-smokers subjects].

Acta cientifica venezolana·2005

Antioxidant vitamins E and C reduce LDL affinity for arterial proteoglycans, a key factor in atherosclerosis. Combining vitamins E and C showed a synergistic effect, offering potential antiatherogenic benefits.

Area of Science:

Biochemistry
Cardiovascular Science
Nutritional Science

Context:

Atherosclerosis development involves Low-Density Lipoprotein (LDL) interaction with arterial proteoglycans and oxidative modification.
Understanding factors influencing this interaction is crucial for developing preventative strategies.

Purpose:

To investigate the effects of individual and combined administration of vitamin E and vitamin C on LDL affinity for arterial proteoglycans.
To compare these effects in healthy smokers and non-smokers.

Summary:

Subjects received placebos, then vitamin E (400 mg/d), followed by vitamin E plus vitamin C (1000 mg/d).
Vitamin E alone decreased LDL affinity by 19.3% in smokers and 25.2% in non-smokers.
Combined vitamins E and C further reduced LDL affinity by 25.6% in smokers and 30.1% in non-smokers, demonstrating a synergistic effect.

Related Experiment Videos

Impact:

Simultaneous administration of vitamins E and C exhibits a synergistic effect in reducing LDL affinity for arterial proteoglycans.
These findings suggest a potential antiatherogenic role for combined vitamin E and C supplementation.