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[Hemoglobin S in the Venezuelan population]
1Departamento de Bioanálisis, Escuela de Ciencias, Núeleo de Suere, Universidad de Oriente, Cumaná, Venezuela. raquelugove@yahoo.com
Abstract:
Hemoglobin variants were introduced in Venezuela mainly by the descendants of African slaves; their distribution is determined by the flow of these populations into the country. The most prevalent hemoglobin variants are Hb S and Hb C. Hb S has a frequency between 0 and 7% depending on the African component of the region. The study of beta s gene linked haplotypes has been used to investigate the origins of African populations in America. In Venezuela, the beta s mutation is associated with the Benin and Bantu haplotypes (CAR) with a high frequency. According to these results the Africans transported to Venezuela were of Bantu origin as it has been showed by the historical records.
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