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Perl-speaks-NONMEM (PsN)--a Perl module for NONMEM related programming
Lars Lindbom1, Jakob Ribbing, E Niclas Jonsson
1Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. lars.lindbom@farmbio.uu.se
Computer Methods and Programs in Biomedicine
|June 24, 2004
Summary
Perl-speaks-NONMEM (PsN) is a programming library that allows users to leverage NONMEM
Area of Science:
- Pharmacometrics and computational science.
- Software development for scientific applications.
Background:
- NONMEM is the leading nonlinear regression software for population pharmacokinetic/pharmacodynamic (PK/PD) analyses.
- There is a need for tools that integrate NONMEM's capabilities into external applications.
Purpose of the Study:
- To introduce Perl-speaks-NONMEM (PsN), an object-oriented programming library in Perl.
- To facilitate the use of NONMEM's computational power within external software.
Main Methods:
- PsN is an object-oriented library written in Perl.
- It utilizes classes designed around NONMEM's data, model, and output files.
- Methods are provided for common tasks like output summarization and parameter initialization.
Main Results:
- PsN simplifies the management and modification of NONMEM model and data files.
- It offers streamlined access to NONMEM run outputs.
- The library automates repetitive tasks in PK/PD analysis workflows.
Conclusions:
- PsN provides a robust foundation for developing advanced software that utilizes NONMEM.
- It enhances programmer efficiency in creating external applications for PK/PD modeling.
- This library promotes greater integration of NONMEM into broader computational workflows.