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Related Experiment Videos

Transdermal delivery of desmopressin using a coated microneedle array patch system.

Michel Cormier1, Bonny Johnson, Mahmoud Ameri

  • 1Biological Sciences Department, ALZA Corporation, 1900 Charleston Road, Mountain View, CA 94043, USA. mcormier@alzus.jnj.com

Journal of Controlled Release : Official Journal of the Controlled Release Society
|June 24, 2004
PubMed
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Transdermal desmopressin (DDAVP) delivery using microneedles offers a safe and effective alternative for treating enuresis. This novel Macroflux technology achieves high bioavailability and good tolerability in preclinical studies.

Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Biotechnology

Background:

  • Desmopressin is a synthetic peptide hormone primarily used for treating enuresis.
  • Current administration routes (injectable, intranasal, oral) have limitations, including poor suitability for children and variable bioavailability.
  • Transdermal drug delivery offers potential for improved patient compliance and consistent dosing.

Purpose of the Study:

  • To evaluate the feasibility and efficacy of transdermal desmopressin delivery using Macroflux microneedle technology.
  • To assess desmopressin bioavailability, pharmacokinetics, and skin tolerability via transdermal administration.

Main Methods:

  • Desmopressin was coated onto microneedle arrays (Macroflux technology).
  • Arrays were applied to hairless guinea pig skin for 5 or 15 minutes.

Related Experiment Videos

  • Pharmacokinetic parameters, including bioavailability and elimination kinetics, were analyzed.
  • Skin tolerability and residual drug on the skin surface were assessed.

    • Main Results:

    • Pharmacologically relevant desmopressin levels were achieved within 5 minutes.
    • High bioavailability (up to 85%) with acceptable variability (30%) was observed.
    • Elimination kinetics were comparable to intravenous delivery, indicating no significant skin depot formation.
    • Transdermal patches demonstrated good tolerability.

    Conclusions:

    • Transdermal desmopressin delivery via Macroflux microneedle technology is a safe and efficient alternative.
    • This method overcomes limitations of current desmopressin administration routes.
    • Further clinical evaluation is warranted to confirm efficacy in human patients.