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Related Experiment Videos

Acute interstitial nephritis due to cefoperazone.

Dilek Torun1, Siren Sezer, Fazilet Kayaselcuk

  • 1Faculty of Medicine, Baskent University, Adana Teaching and Medical Research Center, Adana, Turkey.

The Annals of Pharmacotherapy
|June 24, 2004
PubMed
Summary

Cefoperazone, a cephalosporin antibiotic, can cause acute interstitial nephritis (AIN), a kidney injury. This case highlights the importance of monitoring renal function in patients receiving this medication.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Pathology

Background:

  • Acute interstitial nephritis (AIN) is a kidney disease often caused by medications.
  • Cephalosporins are a class of antibiotics known to sometimes induce AIN.

Observation:

  • A 35-year-old woman developed acute renal failure with decreased urine output after 15 days of cefoperazone therapy.
  • Renal biopsy revealed inflammatory infiltrate in the interstitium, supporting AIN diagnosis.
  • The patient recovered renal function after discontinuing cefoperazone and initiating corticosteroid treatment.

Findings:

  • This case represents the first reported instance of cefoperazone-induced acute interstitial nephritis.
  • Diagnosis was confirmed by clinical presentation, urinalysis, eosinophilia, renal biopsy, and response to corticosteroids.

Related Experiment Videos

  • The Naranjo probability scale indicated a probable link between cefoperazone and the patient's acute renal failure.

    • Implications:

    • Cefoperazone, similar to other cephalosporins, poses a risk of causing AIN.
    • Close monitoring of renal function is recommended for patients treated with cefoperazone.
    • This case underscores the need for vigilance regarding antibiotic-induced kidney injury.