Related Experiment Video
Updated: Aug 23, 2026

11:39
A Quantitative Fitness Analysis Workflow
Published on: August 13, 2012
A genome-wide telomere screen in yeast: the long and short of it all
Dawn Edmonds1, Bobby-Joe Breitkreutz, Lea Harrington
1Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 620 University Avenue, Toronto, ON, Canada M5G 2C1.
Abstract
No abstract available in PubMed .
Related Concept Videos
Replication in Eukaryotes
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes
Overview
Telomeres and Telomerase
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.

