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Related Experiment Videos

Acute lymphoblastic leukemia in infants.

Aytemiz Gürgey1, Sevgi Yetgin, Mualla Cetin

  • 1Section of Hematology, Department of Pediatrics, Hacettepe University, Faculty of Medicine, Ankara, Turkey.

The Turkish Journal of Pediatrics
|June 25, 2004
PubMed
Summary

Treatment for infant acute lymphoblastic leukemia (ALL) improved significantly over time. Newer protocols (Total Therapy XI and XIII) demonstrated better event-free survival rates compared to earlier regimens.

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Area of Science:

  • Pediatric Oncology
  • Hematology
  • Clinical Trials

Background:

  • Infant acute lymphoblastic leukemia (ALL) historically has a poor prognosis.
  • Treatment advancements are crucial for improving outcomes in this vulnerable population.

Purpose of the Study:

  • To evaluate the efficacy of sequential treatment protocols for newly diagnosed infants with ALL.
  • To compare event-free survival rates between different treatment eras.

Main Methods:

  • Retrospective analysis of 29 infants with ALL treated between 1978 and 1999.
  • Group 1 (1978-1991): Two- or three-drug induction with prednisolone, vincristine, L-asparaginase, and 3-year maintenance (mercaptopurine, methotrexate).
  • Group 2 (1991-1999): St. Jude Total Therapy XI and XIII protocols with modifications.

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Main Results:

  • Three-year event-free survival was 14% in Group 1.
  • Event-free survival in Group 2 was 25% (Total XI) and 57% (Total XIII).
  • Outcomes significantly improved with Total Therapy XI and XIII protocols compared to Group 1.

Conclusions:

  • Sequential treatment protocols have progressively improved outcomes for infants with ALL.
  • The St. Jude Total Therapy XI and XIII protocols represent significant advancements in infant ALL treatment.
  • Further research into optimized therapies for infant ALL is warranted.