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Related Experiment Videos

Plaque-type intertriginous cutaneous calcification.

R S Jurzyk1, C M Ditre, G R Kantor

  • 1Division of Dermatology, Hahnemann University, Philadelphia, Pennsylvania 19102-1192.

Cutis
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

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This study details a rare case of cutaneous calcification in a patient with systemic lupus erythematosus on hemodialysis. The patient exhibited both dystrophic and metastatic calcification types, including unusual elastic fiber calcification.

Area of Science:

  • Dermatology
  • Nephrology
  • Rheumatology

Background:

  • Cutaneous calcification presents in four main types: dystrophic, idiopathic, tumoral, and metastatic.
  • Systemic lupus erythematosus (SLE) is an autoimmune disease often requiring complex management, including hemodialysis.
  • Corticosteroid therapy, common in SLE, can lead to skin changes like striae.

Observation:

  • A patient with SLE undergoing hemodialysis developed extensive plaque-like cutaneous calcifications.
  • Calcifications were noted in the axillae and groin, some overlying striae from prior corticosteroid use.
  • Histological examination revealed calcification of elastic fibers, mimicking pseudoxanthoma elasticum.

Findings:

  • The case demonstrated a rare combination of dystrophic and metastatic cutaneous calcification.

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  • The clinical presentation and histological findings were unusual, particularly the elastic fiber involvement.
  • This presentation highlights the diverse manifestations of calcification in patients with chronic kidney disease and autoimmune conditions.

    • Implications:

    • This case expands the understanding of cutaneous calcification types and their association with systemic diseases.
    • It underscores the importance of considering diverse calcification patterns in patients with SLE and chronic kidney disease.
    • The findings suggest potential links between calcification, elastic tissue, and specific therapeutic interventions in complex systemic diseases.