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High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany
R R Reinert1, R Lütticken, A Al-Lahham
1Institute of Medical Microbiology, National Reference Centre for Streptococci, University Hospital, Aachen, Germany. Reinert@rwth-aachen.de
Abstract:
An isolate of Streptococcus pyogenes isolated from a 63-year-old woman with a serious wound infection was found to be highly resistant to fluoroquinolones (levofloxacin MIC > or = 32 mg/L). DNA amplification and sequencing revealed a serine-81 to phenylalanine substitution in gyrA and three substitutions in parC: serine-79 to phenylalanine, aspartic acid-91 to asparagine, and serine-140 to proline. To our knowledge, this is the first report from a European country of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.
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