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Cardiac output measurement by pulse dye densitometry using three wavelengths
Nobuko Taguchi1, Satoshi Nakagawa, Katsuyuki Miyasaka
1Department of Anesthesia and the Intensive Care Unit, National Center for Child Health and Development, Tokyo, Japan.
Summary
A new prototype Pulse Dye Densitometry (PDD) system accurately measures cardiac output (CO) in piglets. This less invasive PDD method shows good correlation with ultrasound, offering a potential bedside tool for pediatric patients.
Area of Science:
- Cardiovascular Physiology
- Medical Device Technology
- Pediatric Critical Care
Background:
- Cardiac output (CO) monitoring is crucial in pediatric critical care.
- Existing methods for CO measurement can be invasive or complex.
- Pulse Dye Densitometry (PDD) offers a potentially less invasive approach.
Purpose of the Study:
- To evaluate the accuracy of a novel prototype PDD system for CO measurement in pediatric patients.
- To compare PDD measurements with a standard ultrasound flowmeter in a preclinical model.
Main Methods:
- A laboratory investigation was conducted using 15 young piglets (approx. 10 kg).
- CO was measured using general anesthesia, intravenous indocyanine green dye, and the prototype PDD system.
- Simultaneous CO measurements were obtained using an ultrasound flowmeter placed on the ascending aorta.
Main Results:
- The PDD system demonstrated good correlation with the ultrasound flowmeter for CO measurements.
- Bias between PDD and ultrasound measurements was 33.8 mL/min, with a precision of 293.4 mL/min.
- Measurements were taken under various hemodynamic conditions.
Conclusions:
- The prototype PDD device achieved acceptable bias and precision for CO measurement in piglets.
- This three-wavelength PDD system offers a simple, less invasive bedside CO monitoring solution.
- The PDD system holds promise for critically ill infants and children.