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rpoB mutations in Streptococcus mitis clinical isolates resistant to rifampin
Wafa Achour1, Olfa Guenni, Marguerite Fines
1Laboratoire du Centre National de Greffe de Moelle Osseuse, 1006 Tunis, Tunisia.
Antimicrobial Agents and Chemotherapy
|June 25, 2004
Abstract:
Activity of rifampin against 129 Streptococcus mitis isolates obtained from patients with hematologic cancer was investigated. One hundred twenty-five strains were susceptible to rifampin, and 4 were resistant (MIC = 32 to 64 microg/ml). Resistance to rifampin was related to mutations in the rpoB gene: His(526)Asn in three strains and His(526)Asp in one strain.