Jove
Visualize
Contact Us

Related Experiment Videos

Biomarkers and Parkinson's disease.

A W Michell1, S J G Lewis, T Foltynie

  • 1Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, CB2 2PY, UK. awm13@cam.ac.uk

Brain : a Journal of Neurology
|June 25, 2004
PubMed
Summary

Biomarkers offer hope for diagnosing Parkinson's disease (PD) and evaluating treatments. This review examines current PD biomarkers, their limitations, and future diagnostic and therapeutic strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human embryonic stem cell-derived dopaminergic cells for Parkinson's disease: a phase 1/2 open-label trial.

Nature medicine·2026
Same author

Deep brain stimulation is well tolerated and effective following ProSavin® gene therapy for Parkinson's disease.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2025
Same author

A 14-year longitudinal study of neurofilament light chain dynamics in premanifest and transitional Huntington's disease.

Journal of neurology·2024
Same author

Early constipation predicts faster dementia onset in Parkinson's disease.

NPJ Parkinson's disease·2021
Same author

Social cognition in Parkinson's disease.

Parkinsonism & related disorders·2021
Same author

Current Concepts and Controversies in the Management of REM Sleep Behavior Disorder.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2021
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Neurology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Parkinson's disease (PD) is a complex neurodegenerative disorder with no definitive diagnostic test.
  • Clinical symptoms of PD fluctuate, complicating study and treatment assessment.
  • Current diagnostic methods rely on clinical observation, highlighting the need for objective measures.

Purpose of the Study:

  • To review current potential biomarkers for Parkinson's disease.
  • To discuss the challenges and limitations associated with the use of these biomarkers.
  • To explore future alternatives for Parkinson's disease diagnosis and treatment evaluation.

Main Methods:

  • Literature review of existing studies on Parkinson's disease biomarkers.
  • Analysis of the validation status and clinical utility of various biomarkers.
  • Discussion of the potential pitfalls and limitations in biomarker application.

Main Results:

  • Several potential biomarkers exist for Parkinson's disease, but none are currently definitive.
  • Validation and standardization of biomarkers remain significant challenges.
  • Biomarkers show promise for diagnosis, prognosis, and monitoring treatment efficacy.

Conclusions:

  • Biomarkers are crucial for advancing Parkinson's disease research and clinical practice.
  • Careful validation is essential to understand the specific applications and limitations of each biomarker.
  • Future research should focus on developing and validating novel biomarkers for early diagnosis and personalized treatment.

Related Experiment Videos