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DIALIGN: multiple DNA and protein sequence alignment at BiBiServ.

Burkhard Morgenstern1

  • 1University of Göttingen, Institute of Microbiology and Genetics, Goldschmidtstr. 1, 37077 Göttingen, Germany. bmorgen@gwdg.de

Nucleic Acids Research
|June 25, 2004
PubMed
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DIALIGN is a versatile software for DNA and protein sequence alignment, combining local and global features for challenging datasets. A new downloadable version and the AltAVisT comparison tool are now available.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Multiple sequence alignment is crucial for understanding DNA and protein function.
  • Traditional alignment methods struggle with complex or divergent sequence data.
  • DIALIGN is an established tool for addressing these limitations.

Purpose of the Study:

  • To introduce enhanced features of the DIALIGN software.
  • To present the AltAVisT program for comparing alignment tool outputs.
  • To provide accessible bioinformatics resources via BiBiServ.

Main Methods:

  • Utilizing a hybrid approach combining local and global alignment strategies in DIALIGN.
  • Developing the AltAVisT software for comparative analysis of sequence alignments.

Related Experiment Videos

  • Distributing DIALIGN and AltAVisT through the Bielefeld Bioinformatics Server (BiBiServ).

    • Main Results:

    • DIALIGN effectively aligns sequence data not amenable to traditional methods.
    • The downloadable DIALIGN version includes new functionalities.
    • AltAVisT facilitates the evaluation of different alignment program outputs.

    Conclusions:

    • DIALIGN remains a powerful and flexible tool for multiple sequence alignment.
    • The availability of new features and comparison tools enhances its utility.
    • BiBiServ provides a valuable platform for accessing these bioinformatics resources.