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Effects of isothiocyanates on tumor necrosis factor-alpha production by J774A.1 (BALB/c macrophage) cells

Yoshio Ohta1, Kohji Yamaki, Toshihiko Osawa

  • 1Hiroshima Prefectural Food Technology Research Center, Hiroshima, Japan.

Bioscience, Biotechnology, and Biochemistry
|June 25, 2004
PubMed

The effects of isothiocyanates (ITCs) on tumor necrosis factor-alpha (TNF-alpha) production by the J774A.1 mouse macrophage cell line stimulated with lipopolysaccharide (LPS) were examined. Some individual ITCs examined showed a priming effect, which was expressed as pre-activation, but also inhibited the production of TNF-alpha with concomitant stimulation by LPS, as a triggering stimulant of TNF production. These results suggest that ITCs exert opposing activities that can enhance or inhibit the host defense system.

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