Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

THE SIGNIFICANCE OF TOTAL PROXIMAL ANTERIOR DESCENDING VESSEL OCCLUSION.

Paul S. Swaye1, Arthur J. Gosselin

  • 1Cardiopulmonary Laboratory, Department of Medicine, Miami Heart Institute, Miami Beach, Florida.

Cardiovascular Diseases
|January 1, 1976
PubMed
Summary

This study on left anterior descending artery occlusion found that collateral circulation is vital for normal left ventricular function. Occlusion site did not influence aneurysm or infarction development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Evaluation of a new modified pediatric bubble oxygenator.

Cardiovascular diseases·1981
Same journal

The reality of a self-occluding pump head: Case report.

Cardiovascular diseases·1981
Same journal

A clinical trial of the Bentley BOS-5 pediatric oxygenator.

Cardiovascular diseases·1981
Same journal

Iatrogenic myocardial dysfunction after formalization of the heart.

Cardiovascular diseases·1981
Same journal

Use of interposed polytetrafluorethylene (PTFE) graft in distal splenorenal shunt.

Cardiovascular diseases·1981
Same journal

Transection of the aorta for repair of pulmonary artery branch stenosis after creation of a Waterston shunt.

Cardiovascular diseases·1981

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Vascular Biology

Background:

  • The left anterior descending (LAD) coronary artery is a critical vessel supplying the anterior wall of the left ventricle.
  • Occlusion of the LAD can lead to significant myocardial damage and impaired cardiac function.
  • Understanding the impact of LAD occlusion site and collateral circulation is crucial for patient management.

Purpose of the Study:

  • To analyze the characteristics of patients with total occlusion of the proximal LAD.
  • To investigate the relationship between LAD occlusion location, collateral vessel formation, and left ventricular function.
  • To determine if occlusion site influences the development of ventricular aneurysms or anterior wall infarction.

Main Methods:

  • Retrospective analysis of 100 consecutive patients with total proximal LAD occlusion identified by cineangiography.

Related Experiment Videos

  • Assessment of occlusion site relative to the first septal branch.
  • Evaluation of collateral vessel presence and extent.
  • Left ventriculography to assess contractility and identify aneurysms.
  • Electrocardiogram (EKG) analysis for signs of infarction.

    • Main Results:

    • Eighty-three percent of patients had collateral vessels supplying the LAD.
    • Normal left ventricular contractility was observed in 16% of patients, all of whom had demonstrable collaterals.
    • Ventricular aneurysms were present in 22% of patients.
    • Anterior wall infarction by EKG was seen in 42% of patients.
    • The location of LAD occlusion (proximal to or beyond the first septal branch) did not correlate with aneurysm formation or EKG-documented infarction.

    Conclusions:

    • Collateral circulation is essential for maintaining normal left ventricular contractility in the presence of LAD occlusion.
    • The anatomical location of LAD occlusion does not appear to predict the development of left ventricular aneurysm or anterior wall infarction.
    • These findings highlight the protective role of collateral vessels in LAD occlusive disease.