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MACROSCOPIC, MICROSCOPIC, AND MECHANICAL ANALYSES OF PROTOTYPE DOUBLE VELOUR VASCULAR GRAFTS.

Daniel A. Holub1, Ruben Trono, Tomas Klima

  • 1Cardiovascular Surgical Research Laboratories, the Department of Surgery, and the Department of Pathology, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, Houston, Texas.

Cardiovascular Diseases
|December 1, 1978
PubMed
Summary

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New Dacron polyester arterial grafts using terry cloth derivatives show improved healing. These experimental vascular grafts promote better fibrous tissue ingrowth, leading to more uniform and stable neointimal formation.

Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Textile Engineering

Background:

  • Current vascular grafts face challenges with uniform fibrous tissue attachment and ingrowth.
  • Existing Dacron polyester grafts (Microvel®, Cooley Double Velour®) utilize double velour construction.
  • The need for enhanced neointimal formation at blood-contacting surfaces is critical for graft patency.

Purpose of the Study:

  • To evaluate prototype double velour tube grafts fabricated from terry cloth derivatives of Dacron polyester.
  • To determine if terry cloth derivatives enhance fibrous tissue attachment and ingrowth for improved neointimal formation.
  • To compare the performance of lighter denier, higher porosity grafts versus heavier denier, lower porosity grafts.

Main Methods:

  • In-vivo and ex-vivo evaluations of prototype Dacron polyester tube grafts.

Related Experiment Videos

  • Implantation of grafts into the abdominal aortas of dogs for 1 to 6 months.
  • Macroscopic and microscopic examination of explanted grafts, focusing on neointimal analysis and endothelialization.

    • Main Results:

    • Both prototype grafts remained patent throughout the study period.
    • The lighter denier, higher porosity prototype demonstrated more homogeneous blood-contacting surfaces.
    • This prototype also exhibited smoother contours and more complete endothelialization compared to the heavier denier graft.

    Conclusions:

    • Prototype double velour grafts from terry cloth derivatives possess properties of useful arterial prostheses.
    • These grafts are not prone to early thrombosis and exhibit rapid healing.
    • Terry cloth derivatives create a more uniform velour pile, leading to more uniform and biologically stable neointimas.