Related Experiment Video
Updated: Aug 14, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
Published on: April 25, 2014
SIGNIFICANCE OF ANGIOGRAPHIC ABSENCE OF LEFT ANTERIOR DESCENDING CORONARY ARTERY IN A LEFT VENTRICLE WITH INTACT
Adib H. Sabbagh1, Lee I. Schocket, Richard L. Dexter
1Department of Surgery, Tucson Medical Center, and St. Mary's Hospital and Health Center, Tucson, Arizona.
Insights
In patients with blocked left anterior descending (LAD) arteries but intact anterior walls, the LAD vessel is often still open and suitable for bypass surgery. This finding provides an additional criterion for considering aortocoronary bypass surgery.
Area of Science:
- Cardiology
- Vascular Surgery
- Diagnostic Imaging
Background:
- Total occlusion of the proximal left anterior descending (LAD) coronary artery is a significant finding in cardiovascular disease.
- Assessing the patency and surgical candidacy of occluded coronary arteries is crucial for treatment planning.
- The integrity of the left ventricular anterior wall may influence the assessment of LAD artery viability.
Purpose of the Study:
- To investigate the patency and potential for bypass surgery in patients with total proximal LAD occlusion.
- To determine if an intact anterior ventricular wall is associated with a patent LAD vessel despite angiographic non-visualization.
- To identify additional criteria for selecting patients for aortocoronary bypass surgery.
Main Methods:
- Study included fifteen patients with total occlusion of the proximal LAD coronary artery.
- Assessed left ventricular anterior wall status via echocardiography or other imaging modalities.
- Evaluated electrocardiogram (ECG) findings for evidence of infarction, ischemia, or conduction abnormalities.
- Assessed for collateral circulation to the affected area.
Main Results:
- All fifteen patients exhibited normal left ventricular anterior walls.
- Collateral circulation was present in twelve patients (80%).
- ECG findings varied, including normal ECGs, old inferior wall infarction, anterior ischemia, and left anterior hemiblock.
Conclusions:
- An angiographically non-visualized LAD vessel can be patent and suitable for bypass surgery in patients with intact anterior ventricular walls.
- The presence of an intact anterior wall serves as an important indicator of LAD vessel viability.
- These findings suggest an additional criterion for considering aortocoronary bypass surgery in selected patients.
Abstract:
Fifteen patients having total occlusion of the proximal left anterior descending coronary artery were studied. All fifteen had normal left ventricular anterior walls. The electrocardiogram was normal in eight patients; old inferior wall infarction was evident in one; anterior ischemia in five; and left anterior hemiblock in one. Collateral circulation was found in twelve patients (80%). These findings suggest that an angiographically non-visualized left anterior descending (LAD) vessel is patent and bypassable in patients where the anterior ventricular wall is intact, thus representing an additional criterion for aortocoronary bypass surgery.
More Related Videos
09:37Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
Published on: December 2, 2014
13:10Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)
Published on: April 24, 2017
Related Concept Videos
Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Cardiac Catheterization III: Left Heart Catheterization
Acute Coronary Syndrome III: Diagnostic Studies