Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coronary dilators and cardioplegia.

Alexander Romagnoli1, Adolph J. Koska

  • 1Cardiovascular Anesthesia Division, Texas Heart Institute, Houston, Texas.

Cardiovascular Diseases
|December 1, 1981
PubMed
Summary

Adding papaverine or nitroglycerin to cardioplegic solution significantly improves its distribution in the myocardium. Papaverine is a superior coronary dilator, enhancing myocardial protection during open-heart surgery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacodynamics of fentanyl citrate in patients undergoing aortocoronary bypass.

Cardiovascular diseases·1981
Same author

A method of preparing woven Dacron aortic grafts to prevent interstitial hemorrhage.

Cardiovascular diseases·1981
Same author

COMPARATIVE HEMODYNAMIC EFFECTS OF NALBUPHINE AND MORPHINE IN PATIENTS WITH CORONARY ARTERY DISEASE.

Cardiovascular diseases·1978
Same author

THE DANGER OF PREOPERATIVE WITHDRAWAL OF PROPRANOLOL.

Cardiovascular diseases·1974

Area of Science:

  • Cardiovascular Surgery
  • Pharmacology

Background:

  • Myocardial protection is crucial during open-heart surgery.
  • Ensuring adequate distribution of cardioplegic solution is vital for effective protection.

Purpose of the Study:

  • To evaluate the effect of papaverine and nitroglycerin on cardioplegic solution distribution in the myocardium.
  • To determine the efficacy of these agents in enhancing myocardial protection.

Main Methods:

  • Canine heart model used to study myocardial distribution.
  • Indocyanine green employed as a tracer for solution distribution.
  • Comparison of cardioplegic solution with and without papaverine or nitroglycerin.

Main Results:

  • Both papaverine and nitroglycerin improved cardioplegic solution diffusion in the myocardium.
  • Papaverine demonstrated superior coronary dilatory effects compared to nitroglycerin.
  • Enhanced diffusion correlated with improved myocardial protection.

Conclusions:

  • Coronary vasodilation is key to optimizing cardioplegic solution delivery.
  • Papaverine is a promising agent for enhancing myocardial protection during cardiac surgery.
  • Pharmacological manipulation of coronary dilation can improve surgical outcomes.

Related Experiment Videos