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Thoracic aortic thrombi and hypercoagulability.

Michael A. Graham1, Donald B. Butler, John D. Milam

  • 1Departments of Pathology and Surgery, St. Luke's Episcopal Hospital, Texas Medical Center, Houston, Texas.

Cardiovascular Diseases
|December 1, 1981
PubMed
Summary

This study links thoracic aortic mural thrombus to a hypercoagulable state, specifically elevated Factor VIII and fibrinogen, without disseminated intravascular coagulation. Acute peritonitis was the likely cause of this coagulopathy.

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Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Critical Care Medicine

Background:

  • Thoracic aortic mural thrombi are uncommon vascular events.
  • Hypercoagulable states can predispose individuals to thrombotic events.
  • Disseminated intravascular coagulation (DIC) is a known cause of hypercoagulability.

Purpose of the Study:

  • To report an unusual association between thoracic aortic mural thrombus and hypercoagulability.
  • To investigate the specific hemostatic abnormalities present.
  • To identify the potential underlying cause of the hypercoagulable state.

Main Methods:

  • Case report detailing a patient with thoracic aortic mural thrombus.
  • Analysis of laboratory results reflecting the patient's coagulation status.

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  • Clinical assessment to determine the underlying etiology.

    • Main Results:

    • The patient presented with a thoracic aortic mural thrombus.
    • Laboratory findings indicated a hypercoagulable state with elevated Factor VIII and fibrinogen levels.
    • Antithrombin III levels were decreased.
    • Disseminated intravascular coagulation was notably absent.
    • Acute peritonitis was identified as the probable underlying cause.

    Conclusions:

    • Thoracic aortic mural thrombus can occur in the setting of a hypercoagulable state.
    • This hypercoagulability may arise from conditions like acute peritonitis, independent of DIC.
    • Highlights the complex interplay between infection, inflammation, and coagulation in vascular pathologies.