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Updated: Feb 10, 2026

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Morphology of aortic arch obstruction with patent ductus arteriosus

Bruno Marino1, Luigi Chiariello, Corrado Mercanti

  • 1Institutes of Chirurgia del Cuore e dei Grossi Vasi, University of Rome and of Cardiochirurgia, University of Pisa, Italy.

Cardiovascular Diseases
|June 1, 1981
PubMed

Insights

Congenital heart defects like aortic arch obstruction and patent ductus arteriosus often occur with other anomalies. Ventriculo-infundibular malalignment with subaortic stenosis is a common associated finding.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Congenital Heart Disease

Background:

  • Aortic arch obstruction and patent ductus arteriosus are critical congenital heart defects.
  • These conditions often present with complex associated cardiac anomalies.
  • Understanding these associations is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the spectrum of associated cardiac anomalies in hearts with aortic arch obstruction and patent ductus arteriosus.
  • To identify specific patterns and frequencies of co-occurring defects.

Main Methods:

  • Retrospective examination of 31 hearts with aortic arch obstruction and patent ductus arteriosus.
  • Classification of aortic arch obstruction types: complete interruption, atretic isthmus, coarctation, and tubular hypoplasia.
  • Categorization of associated anomalies into septal defects and ventricular inflow/outflow obstructions.

Main Results:

  • Six cases of complete interruption, four of atretic isthmus, twelve of coarctation, and three of tubular hypoplasia were identified.
  • A significant incidence (47.4%) of ventriculo-infundibular malalignment type of ventricular septal defect with subaortic stenosis was observed.
  • Associated lesions potentially reducing fetal aortic arch blood flow may contribute to poor arch development.

Conclusions:

  • Aortic arch obstruction and patent ductus arteriosus are frequently accompanied by other congenital heart anomalies.
  • Ventriculo-infundibular malalignment with subaortic stenosis is a notable associated defect.
  • Fetal hemodynamic factors may play a role in the development of aortic arch abnormalities.

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