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Updated: Aug 23, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
Noninvasive assessment of the stenotic mitral valve orifice by two-dimensional echocardiography
Surendra K. Jain1, Leonard W. Pechacek, Carlos M. Decastro
1Clayton Foundation for Research Cardiovascular Laboratories and the Division of Cardiology of St. Luke's Episcopal Hospital and the Texas Heart Institute, Houston, Texas.
Abstract:
Two-dimensional echocardiographic imaging of the mitral valve orifice was attempted in 26 patients with isolated mitral stenosis. The intention was to examine further the clinical usefulness and limitations of this technique for estimating the severity of mitral stenosis. Technically adequate recordings of the mitral orifice were obtained in 20 patients (77%). Mitral valve area calculated from echocardiography compared favorably to the valve area derived from cardiac catheterization with the use of the Gorlin formula (r = 0.95). The average difference between the two methods was 0.109 cm(2). Two-dimensional echocardiography does provide clinically useful data for predicting the degree of mitral stenosis in the majority of patients provided that critical technical limitations are recognized.
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