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Updated: Aug 23, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
[Prognostication of a complicated course of myopia in children]
Abstract:
The aim of the case study was to define the earliest criteria of the transformation of myopia into its aggravated form. Two related risk factors were isolated on the basis of a comprehensive examination of 135 children and teenagers with uncomplicated myopia of 0.5-16 d and with myopia complicated by different-type peripheral vitreochorioretinal dystrophies (PVCRD). They are primarily a reduced acoustic sclera density in the excavation zone and in the region of the posterior eye pole, diminished antioxidant reserve of the lachrymal fluid and heredity (presence of PVCRD in close relatives). Besides, a mild relationship was established between the eye fundus status in children and teenagers with myopia, on the one hand, and myopia progression rate, linear blood-flow velocity in the ciliary body, relative accommodation reserve and a value of the anterior-posterior eye axis, on the other hand. No reliable correlation was found between the eye fundus status and the below parameters: volumetric and linear blood flows in the ocular artery and in the posterior ciliary arteries, volumetric blood flow velocity in the ciliary body, intraocular pressure values, elastic elevation and rigidity factor. The most significant differences between the complicated and uncomplicated types of myopia in children were registered in its mild degree.
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