Related Experiment Video
Updated: Jul 25, 2026
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
In-vitro activity of nisin against clinical isolates of Clostridium difficile
A Bartoloni1, A Mantella, B P Goldstein
1Clinica Malattie Infettive, Università di Firenze, Ospedale di Careggi, Viale Morgagni 85, I-50134 Florence, Italy. bartolonia@ao-careggi.toscana.it
Abstract:
Nisin is a cationic peptide produced by Lactococcus lactis. Its activity against clinical isolates of Clostridium difficile was compared to that of vancomycin and metronidazole by minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill studies. Nisin was more active than the other agents, with a MIC90 of 0.256 mg/L and strong bactericidal activity. Nisin may be a promising agent for the management of C. difficile associated diarrhea.
